Dr. Michael Noseworthy, in his Master’s degree, developed novel MRI approaches to assess anaesthetic induced liver damage (1992). Subsequently he received a PhD (1996) specializing in applications of MRI/MRS and electron paramagnetic resonance (EPR) methods to assess free radical induced brain damage. From 1997-1999, he was a postdoctoral fellow in Imaging Physics, Sunnybrook Health Sciences Centre performing evaluation of tissue microvasculature through correlative MRI and energy dispersive X-ray microanalysis (EDXS). From 1999-2003, Dr. Noseworthy was a MRI physicist at The Hospital for Sick Children and Assistant Professor in Medical Biophysics and Medical Imaging, University of Toronto. He moved to St. Joseph’s Healthcare in August 2003 and following 3 years as Assistant Professor (Radiology and Medical Physics) at McMaster, Dr. Noseworthy was appointed in Electrical & Computer Engineering, where he is now a full professor. In addition, he is Director of Imaging Physics and Engineering at the Imaging Research Centre, at St. Joseph’s Healthcare, Hamilton. Dr. Noseworthy was the Co-Director of the McMaster School of Biomedical Engineering for 10 years (2010-2020).
Dr. Noseworthy’s research interest is the assessment of tissue microstructure and metabolism using multimodal medical imaging. He focuses considerably on MRI and multinuclear in vivo nuclear magnetic resonance (NMR) spectroscopy. His work involves both imaging hardware and software development and more recently machine learning and deep learning. Dr. Noseworthy is a licensed Professional Engineer in Ontario (PEO) and a member of the Institute of Electrical and Electronics Engineers (IEEE), International Society for Magnetic Resonance in Medicine (ISMRM) and European Society for Magnetic Resonance in Medicine and Biology (ESMRMB).
Currently, Dr. Noseworthy’s lab is working on developing robust protocols for brain sodium (23Na) MRI and assessing spatial and temporal complexity of blood oxygen level dependent (BOLD) brain MRI signals. They are also learning optimization of compressed sensing for undersampled MRI scanning and applying machine learning to evaluate structural and functional brain changes following injury.
Expandable List
Engineering Technology Building, Room 406, McMaster University
1280 Main Street West
Email: nosewor@mcmaster.ca
Office Phone: (905) 525-9140 x23727
Professor, Department of Electrical and Computer Engineering, McMaster University
Director, Imaging Physics and Engineering, Imaging Research Centre, St. Joseph’s Healthcare
Special Professional Staff, St. Joseph’s Healthcare (Radiology and Nuclear Medicine)
Danielli, E., Simard, N., Dematteo, C., Kumbhare, D., Ulmer, S. & Noseworthy M.D. (2023) A review of brain regions and associated post-concussion symptoms. Frontiers in Neurology, 14, 1-25.
Ottoy. J, Ozzoude, M., Zukotynski, K., […] Noseworthy, M.D., Prato, F., Sahlas, D., Smith, E., Kuo, P., Chad, J., Pasternak, O., Sossi, V., Thiel, A., Soucy, J-P., Tardif, J-C., Black, S. & Goubran, M. (2023). Amyloid-PET of the white matter: relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease. Journal of Cerebral Blood Flow & Metabolism, 43(6), 921-936.
Ottoy, J., Ozzoude, M., Zukotynski, K., […] Noseworthy, M.D., Prato, F., Sahlas, D., Smith, E., Kuo, P.H., Sossi, V., Thiel, A., Soucy, J-P., Tardif, J-C., Black, S. & Goubran, M. (2023). Vascular burden and cognition: Mediating roles of neurodegeneration and amyloid-PET. Alzheimer’s & Dementia, 19, 1503-1517.
Shah R, Petch J, Nelson W, Roth K, Noseworthy MD, Ghassemi M, Gerstein HC. (2023) Nailfold capillaroscopy and deep learning in diabetes. J. Diabetes 15(2):145-151. (note: I was involved in experimental design, interpretation and editing of each draft of the manuscript).
Sharma B, DeMatteo C, Noseworthy MD, Timmons BW (2023) Sex-specific differences in resting- state functional brain activity in pediatric concussion. Nature Scientific Reports 13: 3284
Sharma. B., Obeid, J., DeMatteo, C., Noseworthy, M.D. & Timmons, B.W. (2023) New insights into accelerometer-measured habitual physical activity and sedentary time during early recovery in pediatric concussion. Pediatric Exercise Science, 16, 1-8.
Simmons, L., Feng, L., Fatemi-Ardekani, A. & Noseworthy, M.D. (2023). Breast cancer calcifications and implications in medical imaging. Critical Reviews in Biomedical Engineering, 51(5), 43-62.
Xu, H., Owens, M.M., Farncombe, T., Noseworthy, M.D. & MacKillop, J. (2023). Molecular brain differences and cannabis involvement: A systematic review of positron emission tomography studies. Journal of Psychiatric Research, 162, 44–56.
Zhu, C., Doyle, T. & Noseworthy M.D. (2023) Addressing dataset shift for trustworthy deep learning Diagnostic ultrasound decision support. In Gavrilova, M., Tan, C.J. Kenneth, Coates, M., Hu., Y., Leung, H., Mohammadi, A., Plataniotis, K.N. & de Oliveira, H.R. (Eds.). Transactions on Computational Science XL (pp. 110-128). Berlin: Springer.
Ottoy J, Ozzoude M, Zukotynski K, Kang MS, Adamo S, Scott C, Ramirez J, Swardfager W, Lam B, Bhan A, Mojiri P, Kiss A, Strother S, Bocti C, Borrie M, Chertkow H, Frayne R, Hsiung R, Laforce R, Noseworthy MD, Prato F, Sahlas D, Smith E, Kuo P, Chad J, Pasternak O, Sossi V, Thiel A, Soucy J-P, Tardif J-C, Black S, Goubran M. (2023). Amyloid-PET of the white matter: relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease J. Cerebr. Blood Flow Metab 0(0).
Ottoy J, Ozzoude M, Zukotynski K, Adamo S, Scott C, Gaudet V, Ramirez J, Swardfager W, Cogo- Moreira H, Lam B, Bhan A, Mojiri P, Kang MS, Rabin J, Kiss A, Strother S, Bocti C, Borrie M, Chertkow H, Frayne R, Hsiung R, Laforce R Jr., Noseworthy MD, Prato FS, Sahlas DJ, Smith EE, Kuo PH, Sossi V, Thiel A, Soucy J-P, Tardif J-C, Black SE, Goubran M. (2023). Lower Aβ-PET signal in white matter lesions relates to higher extracellular free water in mixed small vessel disease and Alzheimer’s pathology. Neurology 0(0). (note: I was involved in experimental design, data acquisition, and editing of each draft of the manuscript).
Tajik M, Noseworthy MD. (2022) A review of molecular and genetic factors for determining mild traumatic brain injury severity and recovery. Brain Disorders 8(December 2022)
João F, Alves S, Secca M, Noseworthy MD, Veloso A. (2022) Fatigue effects on the lower leg muscle architecture using diffusion tensor MRI. Appl. Sci. 12:9767.
Samson E, Noseworthy MD (2022). A Review of diagnostic imaging approaches to assessing Parkinson’s Disease. Brain Disorders 6:100037.
Danielli E, Simard N, Sharma B, Doughty M, Noseworthy MD. (2022) Long-term functional, but minimal structural changes present in aging Canadian football league players years after retirement. BrainDisorders.6:100036.
Ottoy J, Ozzoude M, Zukotynski K, Adamo S, Scott C, Gaudet V, Ramirez J, Swardfager W, Cogo- Moreira H, Lam B, Bhan A, Mojiri P, Kang MS, Rabin JS, Kiss A, Strother S, Bocti C, Borrie M, Chertkow H, Frayne R, Hsiung R, Laforce R Jr., Noseworthy MD, Prato FS, Sahlas DJ, Smith EE, Kuo PH, Sossi V, Thiel A, Soucy J-P, Tardif J-C, Black SE, Goubran M. (2022). Vascular burden and cognition: Mediating roles of neurodegeneration and amyloid-PET. Alzheimer’s & Dementia. (note: I was involved in experimental design, data acquisition, and editing of each draft of the manuscript).
Ahmed B, Varah N, Ong F, Blondin D, Gunn E, Konyer N, Singh N, Noseworthy MD, Haman F, Carpentier A, Punthakee Z, Steinberg G, Morrison K. (2022) Impaired cold stimulated supraclavicular brown adipose tissue activity in young boys with obesity. Diabetes 71(6):1193-1204. (note: I was involved in experimental design, interpretation and editing of each draft of the manuscript).
Sharma B, Obeid J, DeMatteo C, Noseworthy MD, Timmons BW. (2022) Exploring the relationship between resting state intra-network connectivity and accelerometer-measured physical activity in pediatric concussion: A cohort study. Appl. Physiol. Nutr. Metab. 47(10):1014-1022.
Caterini JE, Ratjen F, Noseworthy MD, Schneiderman JS, Rayner T, Weiss R, Williams C, Barker A, Wells GD. (2022). Non-invasive MR imaging techniques for measuring femoral arterial flow in a pediatric and adolescent cohort. Physiol. Reports 10:e15182 (note: I was involved in experimental design, methods, mathematical modeling, statistics validation and editing of each draft of the manuscript).
Gatti AA, Keir PJ, Noseworthy MD, Maly MR. (2022) Investigating acute changes in osteoarthritic cartilage by integrating biomechanics and statistical shape models of bone: Data from the osteoarthritis initiative. Magn Reson Mater Phy (MAGMA). 14:1–13.
Gatti AA, Kier P, Beauchamp M, Noseworthy MD, Maly MR. (2022). Equations to prescribe bicycle saddle height based on desired joint kinematics and bicycle geometry. Eur. J Sport Sci. 22(3):344-353.
Polak P, Schulte RF, Noseworthy MD. (2022) An approach to evaluation of the point spread function (PSF) for 23Na MRI. NMR in Biomedicine 2022 Feb;35(2):e4627.
McGillivray JE, Debruin H, Kumbhare DA, Noseworthy MD. (2021). The Effect of exercise on neural activation and cognition: A review of task based fMRI studies. Crit. Rev. Biomed Eng. 49(2):21-52.
Anand, S. S., Friedrich, M. G., Desai, D., Schulze, K. M., Awadalla, P., Busseuil, D., … Smith, E. E. (2020). Reduced Cognitive Assessment Scores among Individuals with Magnetic Resonance Imaging-Detected Vascular Brain Injury. Stroke, 51(4), 1158–1165. (**Dr. Noseworthy was involved in data acquisition, plus editing of each draft of the manuscript).
Považan, M., Mikkelsen, M., Berrington, A., Bhattacharyya, P. K., Brix, M. K., Buur, P. F., … Barker, P. B. (2020). Comparison of multivendor single-voxel MR spectroscopy data acquired in healthy brain at 26 sites. Radiology, 295(1), 171–180. (**Dr. Noseworthy was involved in data acquisition and analysis, plus editing of each draft of the manuscript).
Harasym, D., Turco, C. V., Nicolini, C., Toepp, S. L., Jenkins, E. M., Gibala, M. J., … Nelson, A. J. (2020). Fitness Level Influences White Matter Microstructure in Postmenopausal Women. Frontiers in Aging Neuroscience, 12, 129.
Ruiter, K. I., Boshra, R., DeMatteo, C., Noseworthy, M., & Connolly, J. F. (2020). Neurophysiological markers of cognitive deficits and recovery in concussed adolescents. Brain Research, 1746, 146998.
Ho, R. A., Hall, G. B., Noseworthy, M. D., & DeMatteo, C. (2020). Post-concussive depression: evaluating depressive symptoms following concussion in adolescents and its effects on executive function. Brain Injury, 34(4), 520–527.
Santos-Díaz, A., & Noseworthy, M. D. (2020). Phosphorus magnetic resonance spectroscopy and imaging (31P-MRS/MRSI) as a window to brain and muscle metabolism: A review of the methods. Biomedical Signal Processing and Control, Vol. 60, p. 101967.
Mikkelsen, M., Rimbault, D. L., Barker, P. B., Bhattacharyya, P. K., Brix, M. K., Buur, P. F., … Edden, R. A. E. (2019). Big GABA II: Water-referenced edited MR spectroscopy at 25 research sites. NeuroImage, 191, 537–548.
Santos-Díaz, A., Harasym, D., & Noseworthy, M. D. (2019). Dynamic 31 P spectroscopic imaging of skeletal muscles combining flyback echo-planar spectroscopic imaging and compressed sensing. Magnetic Resonance in Medicine, 81(6), 3453–3461.
Santos-Díaz, A., & Noseworthy, M. D. (2019). Comparison of compressed sensing reconstruction algorithms for 31 P magnetic resonance spectroscopic imaging. Magnetic Resonance Imaging, 59, 88–96.
McNabb, E., Wong, R., & Noseworthy, M. D. (2019). Differentiating platinum coated brachytherapy seeds and gold fiducial markers with varying off-resonant frequency offsets. Magnetic Resonance Imaging, 60, 68–75.
Harasym, D., Nelson, A. J., & Noseworthy, M. D. (2019). Sources of variability and improvements in the measure of gaba using mega-press at 3t. Critical Reviews in Biomedical Engineering, 47(5), 437–455.
Ruiter, K. I., Boshra, R., Doughty, M., Noseworthy, M., & Connolly, J. F. (2019). Disruption of function: Neurophysiological markers of cognitive deficits in retired football players. Clinical Neurophysiology, 130(1), 111–121.
DeMatteo, C. A., Lin, C.-Y. A., Foster, G., Giglia, L., Thabane, L., Claridge, E., … Connolly, J. F. (2019). Evaluating Adherence to Return to School and Activity Protocols in Children After Concussion. Clinical Journal of Sport Medicine, Publish Ahead of Print(00).
Ho, R. A., Hall, G. B., Noseworthy, M. D., & DeMatteo, C. (2018). An Emotional Go/No-Go fMRI study in adolescents with depressive symptoms following concussion. International Journal of Psychophysiology, 132, 62–73.
McNabb, E., Wong, R., & Noseworthy, M. D. (2018). Resolution and registration in dual-plane co-RASOR MR. Physics in Medicine & Biology, 63(21), 215005.
- Alejandro Amador-Tejada, PhD Student, School of Biomedical Engineering, McMaster University
- Konrad Grala, MSc Student, School of Biomedical Engineering, McMaster University
- Aravinthan Jegatheesan, PhD Student, School of Biomedical Engineering, McMaster University
- Cameron Nowikow, PhD Student, School of Biomedical Engineering, McMaster University
- Ethan Samson, PhD Student, School of Biomedical Engineering, McMaster University
- Dr. Bhanu Sharma, Postdoctoral Fellow, Electrical and Computer Engineering, McMaster University.
- Nicolas Simard, PhD Student (Co-Supervision), Department of Electrical and Computer Engineering, McMaster University
- Lyndsay Simmons, PhD Student, School of Biomedical Engineering, McMaster University
- Mahnaz Tajik, PhD Student, School of Biomedical Engineering, McMaster University
- Mitra Tavakkoli, PhD Student, School of Biomedical Engineering, McMaster University
- Calvin Zhu, PhD Student, School of Biomedical Engineering, McMaster University